What happens when Marvels Spider-Man and Venom have a face-off? Well, according to Venom's director, Ruben Fleischer, this soon might come true. 

venom
Source: Full circle cinema

That's right! During a recent interview Fleischer mentioned, 

That’s where it’s all going to lead. And that’s the exciting thing, because we changed the origin of Venom … in the comics, he evolved from Spider-Man but because of the Marvel-Sony thing we weren’t able to that. And so the thing I think it’s building towards, and will be exciting to see, is when they actually do confront each other. 
venom
Source: Wordpress

This news also confirmed that our favourite super villain, Tom Hardy will be reprising the role of Eddie Brock in the sequel. 

venom
Source: Movie web

Spider-Man's existence in the MCU was earlier in jeopardy when Sony reported that Marvel's parent company - Disney couldn't reach a new deal to continue having Spider-Man with them.  

However, a new deal was finally struck and Spider-Man remains in the MCU for at least one more solo movie or teaming up. 

spidey
Source: Ladbible

So, while Spider-Man's entry in MCU (again) is a great news for all the fans, if this crossover between the superhero (Spider-Man) and the supervillain (Venom) happens, it will be one hell of a ride.